Unlocking Critical Periods. Biological basis and reversibility

Our lab explores how brain functions are shaped by early life experience, identifying pivotal roles for specific inhibitory circuit ‘triggers’ and molecular ‘brakes’ which can be lifted to enable adult plasticity. Originally identified in sensory systems of mice, these principles provide novel insights into the development of higher cognitive function and the human condition — shedding light on the etiology, biomarkers and potential reversibility of derailed neurodevelopmental trajectories in cognitive disorders, early adversity, recovery from brain injury in adulthood, and life-long learning more broadly.

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