This course covers some of the most important methodological issues arising in any field of applied economics when the main scope of the analysis is to estimate causal effects. A variety of methods will be illustrated using theory and papers drawn from the recent applied literature. The aim is to bridge the step from a technical econometrics course to doing applied research. The emphasis will be on the applications. The goal is to provide students with enough knowledge to understand when these techniques are useful and how to implement each method in their empirical research.